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Morphea: The 2023 update

Cristian Papara, David A. De Luca, Katja Bieber, Artem Vorobyev, Ralf J. Ludwig

Front Med (Lausanne) 2023; 10: 1108623. Published online 2023 Feb 13. doi: 10.3389/fmed.2023.1108623

PMCID:: PMC9969991

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Morphea and Eosinophilic Fasciitis: An Update

Jorre S. Mertens, Marieke M. B. Seyger, Rogier M. Thurlings, Timothy R. D. J. Radstake, Elke M. G. J. de Jong

Am J Clin Dermatol. 2017; 18(4): 491–512. Published online 2017 Mar 16. doi: 10.1007/s40257-017-0269-x

PMCID:: PMC5506513

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Update on Management of Morphea (Localized Scleroderma) in Children

Renu George, Anju George, T. Sathish Kumar

Indian Dermatol Online J. 2020 Mar-Apr; 11(2): 135–145. Published online 2020 Mar 9. doi: 10.4103/idoj.IDOJ_284_19

PMCID:: PMC7247622

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Morphea: progress to date and the road ahead

Laila Abbas, Adrienne Joseph, Elaine Kunzler, Heidi T. Jacobe

Ann Transl Med. 2021 Mar; 9(5): 437. doi: 10.21037/atm-20-6222

PMCID:: PMC8033330

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Localized scleroderma: clinical spectrum and therapeutic update

Mariana Figueiroa Careta, Ricardo Romiti

An Bras Dermatol. 2015 Jan-Feb; 90(1): 62–73. doi: 10.1590/abd1806-4841.20152890

PMCID:: PMC4323700

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Interventions for morphea

Julia V de Albuquerque, Brenda NG Andriolo, Monica RA Vasconcellos, Vinicius T Civile, Anne Lyddiatt, Virginia FM Trevisani, Cochrane Skin Group

Cochrane Database Syst Rev. 2019; 2019(7): CD005027. Published online 2019 Jul 16. doi: 10.1002/14651858.CD005027.pub5

PMCID:: PMC6630193

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Autoantibodies in Morphea: An Update

Sangita Khatri, Kathryn S. Torok, Emily Mirizio, Christopher Liu, Kira Astakhova

Front Immunol. 2019; 10: 1487. Published online 2019 Jul 9. doi: 10.3389/fimmu.2019.01487

PMCID:: PMC6634257

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An Evaluation of the Performance of Current Morphea Subtype Classifications

Smriti Prasad, Jane L. Zhu, Kaila Schollaert-Fitch, Kathryn S. Torok, Heidi T. Jacobe

JAMA Dermatol. 2021 Apr; 157(4): 1–8. Published online 2021 Feb 17. doi: 10.1001/jamadermatol.2020.5809

PMCID:: PMC7890441

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Upcoming treatments for morphea

Dan Wenzel, Nazgol‐Sadat Haddadi, Khashayar Afshari, Jillian M. Richmond, Mehdi Rashighi

Immun Inflamm Dis. 2021 Dec; 9(4): 1101–1145. Published online 2021 Jul 17. doi: 10.1002/iid3.475

PMCID:: PMC8589364

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Immunopathogenesis of Pediatric Localized Scleroderma

Kathryn S. Torok, Suzanne C. Li, Heidi M. Jacobe, Sarah F. Taber, Anne M. Stevens, Francesco Zulian, Theresa T. Lu

Front Immunol. 2019; 10: 908. Published online 2019 Apr 30. doi: 10.3389/fimmu.2019.00908

PMCID:: PMC6503092

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Genetic Signatures From RNA Sequencing of Pediatric Localized Scleroderma Skin

Emily Mirizio, Christopher Liu, Qi Yan, Julia Waltermire, Roosha Mandel, Kaila L. Schollaert, Liza Konnikova, Xinjun Wang, Wei Chen, Kathryn S. Torok

Front Pediatr. 2021; 9: 669116. Published online 2021 Jun 7. doi: 10.3389/fped.2021.669116

PMCID:: PMC8215272

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Prediction of Disease Relapse in a Cohort of Juvenile Localized Scleroderma Patients

K. Kurzinski, C. K. Zigler, DR. K. S. Torok

Br J Dermatol. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Br J Dermatol. 2019 May; 180(5): 1183–1189. Published online 2018 Dec 5. doi: 10.1111/bjd.17312

PMCID:: PMC6462250

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Changes in Disease Activity and Damage Over Time in Patients With Morphea

Jack C. O’Brien, Hugh Nymeyer, Allison Green, Heidi T. Jacobe

JAMA Dermatol. 2020 May; 156(5): 1–8. Published online 2020 Apr 1. doi: 10.1001/jamadermatol.2020.0034

PMCID:: PMC7113826

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Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea

Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson, Heidi T. Jacobe

J Transl Med. 2022; 20: 41. Published online 2022 Jan 24. doi: 10.1186/s12967-022-03246-5

PMCID:: PMC8785566

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Intramuscular Polydeoxyribonucleotides in Fibrotic and Atrophic Localized Scleroderma: An Explorative Prospective Cohort Study

Maurizio Romagnuolo, Chiara Moltrasio, Angelo Valerio Marzano, Gianluca Nazzaro, Simona Muratori, Sebastiano Recalcati

Biomedicines. 2023 Apr; 11(4): 1190. Published online 2023 Apr 17. doi: 10.3390/biomedicines11041190

PMCID:: PMC10135559

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Role of imaging in morphea assessment: A review of the literature

Faezeh Khorasanizadeh, Yasamin Kalantari, Ifa Etesami

Skin Res Technol. 2023 Jul; 29(7): e13410. Published online 2023 Jul 3. doi: 10.1111/srt.13410

PMCID:: PMC10318382

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A Comparison of Clinical, Demographic and Treatment Characteristics of Pediatric-Onset and Adult-Onset Patients Diagnosed With Localized Scleroderma

Ayşe Akbaş, Fadime Kılınç, Yıldız Hayran

Dermatol Pract Concept. 2024 Jan; 14(1): e2024023. Published online 2024 Jan 1. doi: 10.5826/dpc.1401a23

PMCID:: PMC10868915

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Therapeutic and Reconstructive Management Options in Scleroderma (Morphea) en Coup de Sabre in Children and Adults. A Systematic Literature Review

Ewelina Ulc, Lidia Rudnicka, Anna Waśkiel-Burnat, Olga Warszawik-Hendzel, Anna Niemczyk, Małgorzata Olszewska

J Clin Med. 2021 Oct; 10(19): 4517. Published online 2021 Sep 29. doi: 10.3390/jcm10194517

PMCID:: PMC8509267

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Factors affecting the concentration of soluble tumour necrosis factor-α receptor type I in the blood serum of patients with localized scleroderma

Martyna Zbiciak-Nylec, Dominika Wcisło-Dziadecka, Ligia Brzeziñska-Wcisło

Postepy Dermatol Alergol. 2020 Aug; 37(4): 524–530. Published online 2020 Sep 2. doi: 10.5114/ada.2020.98239

PMCID:: PMC7507158

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Select item 724801820.

MicroRNA in localized scleroderma: a review of literature

Katarzyna Wolska-Gawron, Joanna Bartosińska, Dorota Krasowska

Arch Dermatol Res. 2020; 312(5): 317–324. Published online 2019 Oct 21. doi: 10.1007/s00403-019-01991-0

PMCID:: PMC7248018

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PMC Images search for morphoea

Figure 2

A 12×6 mm pretibial ulcer with a fibrin bed on the linear morphoea lesion and erythema with ill-defined borders.

A case of ulceroglandular tularemia presenting with lymphadenopathy and an ulcer on a linear morphoea lesion surrounded by erysipelas

Int Med Case Rep J. 2018;11:313-318.
Figure 2

Haematoxylin and eosin stained section (original magnification, ×100) showing later stage morphoea. Thickened collagen bundles fill the reticular dermis in the vicinity of an eccrine gland that has lost the normal surround of adipose tissue.

Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature

Mol Pathol. 2002 Dec;55(6):374-378.
Figure 1

Haematoxylin and eosin stained section (original magnification, ×20) showing early changes of morphoea. A perivascular infiltrate is present in the dermis and the superficial subcutis. The reticular dermis appears pale owing to the presence of swollen collagen bundles.

Morphoea and Borrelia burgdorferi: results from the Scottish Highlands in the context of the world literature

Mol Pathol. 2002 Dec;55(6):374-378.
Figure 1

Main demographic features. Abbreviations: circumscribed morphoea (CM), linear scleroderma (LS), generalized (GM), panclerotic (PM) and mixed morphoea (MM).

Juvenile localized scleroderma: review of 44 patients

Pediatr Rheumatol Online J. 2011;9(Suppl 1):P75-P75.